It is a must win for the Bills, and they need look no further than this past weekend and what the Patriots did to Andrew Luck. New England put pressure on the rookie quarterback, forcing four turnovers, including three interceptions.

For the Bills D: stop the run game and pressure Luck into mistakes.

"I think the one thing we talked about is the big thing is they hang their hat on is their run game and their play action game. So we have to play good run defense and put them in positions where we know what they are going to do. Try to get them one-dimensional and make them throw the ball," said defensive tackle Kyle Williams.